Title: Functional and anatomical evaluation of the effect of nepafenac in prevention of macular edema after phacoemulsification in diabetic patients
Authors: Tharwat Mokbe, Sameh Saleh, Mona Abdelkader, Sherief E. El-khouly,Waleed Abou Samra, Mohamed Mamdouh
Afficilat: Mansoura Ophthlmic Center, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt
AIM: To evaluate the effect of prophylactic administration of nepafenac in prevention of macular edema occurring in diabetic patients after phacoemulsification and to investigate the correlation between optical coherence tomography (OCT) foveal thickness and multifocal electroretinogram (MF-ERG) parameters.
METHODS: The study included two groups. Group 1 included 50 diabetic patients with senile cataract (50 eyes, 30 females, 20 males, aged 55±7y) received nepafenac 0.1% eye drop. Group 2 included another 50 diabetic patients with senile cataract (50 eyes, 22 female, 28 males, aged 53.8±8y) did not receive nepafenac. All patients were followed up for 3mo postoperatively. OCT and MF-ERG were done preoperative and at 1wk, 1, 2 and 3mo.
RESULTS: The mean foveal thickness was statistically significantly lower in Group 1. Five eyes in Group 2 developed clinical cystoid macular oedema (CMO) (10%), and no patients in Group 1 developed central macular thickening more than 50 μm. There were insignificant differences in MF-ERG amplitudes and latencies between the two groups except in the five eyes that developed CMO, there statistically significant reduction of MF-ERG amplitude with increase in foveal thickness.
CONCLUSION: Perioperative nepafenac reduces the incidence of CMO following uncomplicated phacoemulsification significantly. Nepafenac has no side effects.
Full Text Html: http://ies.ijo.cn/en_publish/2019/3/20190306.htm
Key Words: nepafenac; macular edema; cataract surgery; diabetes; optical coherence tomography; multifocal electroretinogram
Prof.Tharwat Mokbel, the Vice President of the Afro-Asian Council of Ophthalmology (AACO), Professor of Ophthalmology and Faculty of Medicine, Mansoura University